(Murcia : F. Hernández, 1987) Schwenk, Jutta; Gosztonyi, Georg
Two cases with brain purpura following Gramnegative
septicaemia were examined morphologically and
immunohistochemically.
The brain lesions, including ball and ring
haemorrhages, a few days old, with some microglial cells
accumulated around the older foci, were restricted to the
white matter.
Immunohistochemically, scanty deposits of IgG, IgA
and IgM mainly in the macrophages in brain, kidneys and
lungs were found, whereas staining with antibodies directed
against IgE and complement (C3, C4) remained negative.
In the brain, immunoglobulin deposits were located mainly
in the macrophages, furthermore, in and around the walls
of a few intact (non-haemorrhagic) vessels; within the
perivascular haemorrhagic foci no deposits could be
demonstrated. The relevance of these observations to the
pathogenesis of brain purpura is discussed.