(Murcia : F. Hernández, 1990) Barnard, H.; Dreef, E.J.; van Krieken, J.H.J.M.
A traumatically ruptured spleen is regarded
as a proper control in many histological and immunological
studies on the human spleen. This paper compares
spleens that ruptured due to trauma and spleens which
were removed during surgery in patients without splenic
pathology. Based on a histological, morphometrical, and
immunohistochemcial description of the control spleens
it is shown that the traumatically ruptured spleens
contain alterations in the lymphoid tissue. The amount of
white pulp is increased due to a larger amount of CD4-
positive lymphocytes. Furthermore there are alterations
in lymphocyte populations in the different splenic
compartments. It is concluded that spleens that rupture
may be predisposed due to immunological stimulation.