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Título: | Immunohistochemical study of macrophage and cytokine dynamics in the gut of scrapie-infected mice |
Fecha de publicación: | 2010 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos |
Palabras clave: | Scrapie Cytokines |
Resumen: | To study numerical changes in intestinal macrophages and variations in cytokine production by immune cells in the intestine, conventional C57BL/6J mice were orally infected with the Rocky Mountain Laboratory strain of scrapie. Animals were sacrificed at different timepoints, and samples were taken and processed by routine methods for morphological and immunohistochemical analysis. The results point to a possible role for macrophages in the uptake and transport of the infective agent to Peyer’s patches. The observed increase in macrophage numbers in subepithelial sites, taken in conjunction with a drop in tumour necrosis factor-α production at these sites, suggests a possible secretory inhibition that could be induced by the disease-associated prion protein (PrPd). On the other hand, cytokine dynamics indicated the presence of an impaired Th1-Th2 cell mediated response, which could facilitate the spread of PrPd to the central nervous system. Further research is required to confirm these hypotheses. |
Autor/es principal/es: | Romero-Trevejo, José Lorenzo Gómez-Villamandos, J. C. Pedrera, Mirian Blanco, Alfonso Bautista, María José Sánchez-Cordón, Pedro José |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/46328 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.25, nº8 (2010) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Immunohistochemical study of macrophage and cytokine dynamics in the gut of scrapieinfected mice.pdf | 2,88 MB | Adobe PDF | Visualizar/Abrir |
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