Period 1 (PER1): A novel glucocorticoid-responsive gene involved in cortisol-induced proliferation of androgen-independent human prostate cancer DU145 cells

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dc.contributor.authorHiroki Shimada
dc.contributor.authorAtsushi Yokoyama
dc.contributor.authorYasuhiro Nakamura
dc.contributor.authorShuko Hata
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-11-10T12:32:30Z
dc.date.available2025-11-10T12:32:30Z
dc.date.issued2025
dc.description.abstractGlucocorticoid receptor (GR) has been implicated in prostate carcinoma and possibly involved in cancer growth and progression. Therefore, in this study, we examined whether the genes involved in cell proliferation regulation were induced by cortisol in androgen-independent human prostate cancer DU145 cells. Gene expression profiling of the DU145 cell pathway was conducted using the RT2 Profile PCR Array System, quantitative reverse transcriptase polymerase chain reaction, and immunoblot analysis. These analyses demonstrated that the expression level of Period 1 (PER1), a gene associated with an organism's biological clock and involved in anti-apoptosis and cell growth, was markedly increased in DU145 cells treated with dexamethasone (DEX). In addition, analysis using short hairpin RNA demonstrated that products of PER1 were involved in the DEX-induced proliferation of DU145 cells. Therefore, PER1 is considered a glucocorticoid-responsive gene that regulates DU145 cell proliferation induced by GR stimulation, thus potentially playing an important role in GR-related androgen-independent human prostate cancer.
dc.formatapplication/pdf
dc.identifier.doihttps://doi.org/10.14670/HH-18-912
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/171971
dc.languageeng
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPeriod
dc.subjectProstate cancer
dc.subjectDexamethasone
dc.subjectGlucocorticoid receptor
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titlePeriod 1 (PER1): A novel glucocorticoid-responsive gene involved in cortisol-induced proliferation of androgen-independent human prostate cancer DU145 cells
dc.typeinfo:eu-repo/semantics/article
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Histology and histopathology, Vol.40, Nº12, (2025)