Expression of mucins MUC1 and MUC4 in curative resected gallbladder adenocarcinoma

Thumbnail Image
Files
Noumi-41-53-60-2026.pdf(3.03 MB)
Date
2026
Authors
Michiyo Higashi
Ikumi Kitazono
Seiya Yokoyama
Takashi Tasaki
Hirotsugu Noguchi
Mari Kirishima
Miki Murakami
Akihide Tanimoto
Masako Noumi
Journal Title
Journal ISSN
Volume Title
Publisher
Editum
Abstract
Background and Aims. Gallbladder adenocarcinoma (GBAC) is associated with high mortality because of the difficulty in its early detection and treatment. Therefore, identifying prognostic factors is crucial for managing patients with GBAC. We aimed to elucidate the relationship between immunohisto-chemical profiles of mucin expression, clinico-pathological behavior, and prognosis for curatively resected gallbladder adenocarcinoma (GBAC) and to prove that mucin expression is a prognostic factor for GBAC. Methods. We examined the expression of mucins (MUC1, MUC2, and MUC4) using immunohisto-chemical analyses and compared the prevalence of each mucin with clinicopathological features in patients with early-stage (stage 0 to IIB) GBAC. Results. MUC1 expression was significantly expressed in patients with GBAC with lymphatic invasion, vascular invasion, perineural invasion, and recurrence. MUC2 was significantly expressed in patients with GBAC with perineural invasion and recurrence but not with prognosis. Patients with MUC1-high expression exhibited worse prognoses than those with MUC1-low expression. In contrast, patients with positive MUC4 expression had significantly better prognoses than those without MUC4 expression. Conclusion. The expression of MUC1 and MUC4 in GBAC is an independent prognostic factor for survival and a useful marker for predicting the outcomes of patients with GBAC.
Description
Keywords
MUC1 , MUC4 , Gallbladder adenocarcinoma (GBAC)
Citation
URI
http://hdl.handle.net/10201/180690
item.page.embargo
Collections
Histology and histopathology, Vol.41, Nº1, (2026)
Ir a Estadísticas