Publication: Projection of forelimb nerve afferents to external cuneate nucleus of the rat as revealed by intraneural injection of a neurotoxic lectin, Ricinus communis agglutinin
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Date
1996
Authors
Cha, S.W. ; Tan, C.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study seeks to extend the observations
of previous studies of projection of primary afferent
fibres from the forelimb nerves and muscles to the
external cuneate nucleus (ECN) of mammals using a
neurotoxic lectin, Ricinus communis agglutinin (RCA) to
achieve chemical ganglionectomy of the dorsal root
ganglia. Following intraneural injection of RCA into the
three main forelimb nerves, namely the radial, ulnar and
median nerves, terminal degeneration of the primary
afferent fibres in the ECN was studied under the light
microscope by means of the Fink-Heimer method. The
results show that the primary afferent fibres from these
three nerves project to the media1 part of the ECN. The
field of terminal degeneration take a crescentic form.
The projection from the median nerve was most dorsally
located whereas that from the radial nerve was the most
ventral with extensive overlaps between them. Of the
three nerves, the projection from the radial nerve was the
most dense. Rostrocaudally, the three nerves also show
extensive overlaps. The rostrocaudal extent of maximum
terminal degeneration was greatest for the radial neme
and least for the median nerve. Analysis of variance
showed that these differences were statistically
significant. This suggests that the radial nerve has the
most extensive projection to the ECN and the median
nerve the least.
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