Publication: Increase of annexin 1 immunoreactivity in spinal cord of newborn opossum (Monodelphis domestica) at the time when regeneration after injury stops being possible
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Date
2007
Authors
Mladinic, M. ; Del Bel, E. ; Nicholls, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Annexins constitute a family of proteins that
associate reversibly with cell membranes in a calcium
dependent manner. We have studied the distribution of
annexin 1, which is known to mediate anti-inflammatory
actions of glucocorticoids, and which is upregulated
after spinal cord injury, in newborn and adult South
American opossum (Monodelphis domestica) spinal
cord. We show the increase in the annexin 1
immunoreactivity in spinal cords of neonatal opossums
over the critical period when regeneration after injury
ceases to be possible. We further show the restricted and
specific sites at which it is detected in adult opossum
cerebellum and hippocampus. Since the procedures used
in immunochemistry of annexin in CNS have in the past
yielded conflicting results, different procedures were
tested and shown to be reliable. As a control, annexin 1
distribution was surveyed in kidney.
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