Publication: Arterial wall neovascularization induced by glycerol
Authors
Díaz Flores, L. ; Madrid, J. F. ; Gutierrez, R. ; Valladares, F. ; Díaz, M. ; Valera, H. ; Díaz Flores Jr, L.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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Description
Abstract
An int e nse a nd sig ni fica nt neo -
vascul ari za tion, with numerous capillaries growing into
th e med ia laye r o f th e rat femo ra l art e ry, was
demonstrated when glycero l was administered into the
interstitium be tween the femoral ve in and the femoral
a rt e ry. Th e max imum mi c rovasc ul a ri za ti o n was
obse rved at days 7 and 9 after glyce rol administration.
Afterwards, invo lution of th e majo rit y of the new lyfo rmed microvessels in the art erial wall occurred. Other
substances containing glyce rol in their molecul es, such
as tri ace tyl-glyce rol and tri butyril-glyce rol, fa il ed to
produce significant neovascul ari zation in the medi a laye r
of the femora l art ery. Neova cul ariza tion of the art eri al
wa ll was preceded by a co nside rab le dec rease in the
number of the smooth muscle ce lls, whi ch ex perienced
apoptosis and necrobiosis, disappearing in extense areas
of the arteri al segment affected by glyce rol. Coinciding
with neovascul ariza tion and mi crovascul ar in volu tion,
repopul ation of the med ia laye r by smooth mu 'cle cells
was observed.
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Citation
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