Publication: Appearance and distribution of stromal myofibroblasts
and tenascin-C in feline mammary tumors
Authors
Yoshimura, Hisashi ; Michishita, Masaki ; Ohkusu-Tsukada, Kozo ; Takahashi, Kimimasa
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Myofibroblasts and extracellular matrix
protein tenascin-C (Tn-C) are known to be implicated in
cancer progression in human cancer. In feline mammary
tumors that are a suitable model for human breast
cancer, however, little is known about stromal
myofibroblasts and no information is available on the
expression of Tn-C. Feline samples of normal mammary
glands and proliferating mammary lesions were
routinely processed and serial sections were cut and
immunostained with anti-α-smooth muscle actin (α-
SMA) or Tn-C antibody. Myofibroblasts were not
included in the stroma of 90% (9/10) of normal
mammary gland tissues, 92% (12/13) of adenosis, and
63% (5/8) of simple adenomas. On the other hand, all 40
simple carcinomas contained stromal myofibroblasts to a
varied extent. Tn-C expression was detected in the
stroma of 92% (37/40) of carcinomas, and its global
distribution almost coincided with that of
myofibroblasts. In addition, Tn-C immunoreactivity was
occasionally observed in the basement membrane zone
around ducts in some cases of normal mammary glands
and benign lesions, but barely observed in the stroma.
These results suggest that stromal myofibroblasts may
be a major cellular source of Tn-C and be involved in
malignant progression of feline mammary tumor.
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