Publication: P53, CD95, cathepsin and survivin pathways in Fuchs dystrophy and pseudophakic bullous keratopathy corneas
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Date
2008
Authors
Szentmáry, Nora ; Szende, Béla ; Süveges, Ildiko
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Our purpose was to elucidate the pathways of
apoptosis of corneas with Fuchs’ dystrophy and
pseudophakic bullous keratopathy. Sixteen corneal
buttons (14 patients, median age 73 years) with Fuchs’
dystrophy, 13 with pseudophakic bullous keratopathy
(PBK) (13 patients, median age 69 years) and 8 buttons
(8 patients, median age 59 years) from enucleated eyes
with chorioideal melanoma (controls) were analysed
histologically. Immunohistochemical analysis was
performed to investigate the expression of p21, p27, p63,
survivin, CD95, cathepsin, bax, bcl-2 and Ki67.
Positive immunohistochemical reactions were
detected in epithelial cells of the corneas, but keratocytes
and endothelial cells were not positive in any of the
groups or stainings. The number of p27 and survivin
positive epithelial cells was significantly lower (p=0.048
and 0.041) and the number of cathepsin positive
epithelial cells was significantly higher (p=0.004) in
Fuchs’ dystrophy corneas compared to controls. In
pseudophakic bullous keratopathy, p21 and p27 positive
epithelial cells were present in a significantly lower
(p=0.02 and 0.005) number than in controls.
We conclude that genetically programmed cell death
is related to the p27, cathepsin and survivin pathways in
Fuchs’ dystrophy and to the p21 and p27 pathways in
pseudophakic bullous keratopathy.
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