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Human axillary apocrine glands: proteins involved in the apocrine secretory mechanism

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dc.contributor.authorStoeckelhuber, Mechthild
dc.contributor.authorSchubert, Christoph
dc.contributor.authorKesting, Marco R.
dc.contributor.authorLoeffelbein, Denys J.
dc.contributor.authorNieberler, Markus
dc.contributor.authorKoehler, Claudia
dc.contributor.authorWelsch, Ulrich
dc.date.accessioned2016-02-08T18:14:45Z
dc.date.available2016-02-08T18:14:45Z
dc.date.issued2011
dc.description.abstractThe apocrine secretory mechanism is a mode of secretion by which the apical part of the cell cytoplasm is pinched off, which leads to the formation of an aposome. The distinct mechanism of formation and decapitation of the aposome is not well investigated. Only few proteins are known that are involved in this secretory mechanism. We studied the human axillary apocrine gland and looked at proteins associated with cytokinesis, a process that is comparable to the pinchingoff mechanism of apocrine glandular cells. By immunohistochemistry, we detected actin, myosin II, cytokeratin 7 and 19, α- and ß-tubulin, anillin, cofilin, syntaxin 2, vamp8/endobrevin and septin 2. In highly active glandular cells, these proteins are located at the base of the apical protrusion when the aposome is in the process of being released or are concentrated in the cap of the apical protrusion. These findings demonstrate new insights on apocrine secretory mechanisms and point to similarites to the terminal step of cytokinesis, which is regulated by a SNARE-mediated membrane fusion event.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/47800
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 2 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAxillary apocrine glandes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleHuman axillary apocrine glands: proteins involved in the apocrine secretory mechanismes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº2 (2011)