Publication: Histopathological changes of the hippocampus neurons in brain injury
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Date
2009
Authors
Dong Ri Li ; Takaki Ishikawa ; Dong Zhao ; Tomomi Michiue ; Li Quan ; Bao Li Zhu ; Hitoshi Maeda
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The glial fibrillary acidic protein (GFAP) is
known as a peculiar marker of mature astrocytes of the
central nervous system (CNS). However, we found
distinct immunopositivity to a monoclonal anti-GFAP
reagent in the hippocampus neurons in head injury
fatalities. The present study investigated the neuronal
and neuroglial GFAP-immunopositivity in the
hippocampus in a series of head injury cases, which
included acute and subacute/delayed deaths (n=17 and
n=73, respectively), and acute cardiac death (n=13),
delayed death due to multiple organ failure from nonhead injury (n=6), and pneumonia (n=9) cases were
examined as controls. GFAP-immunopositivity in the
neurons was frequently observed in CA4, CA3 and CA2
regions in cases of subacute/delayed head injury death
that showed marked brain swelling accompanied by
secondary brain stem hemorrhages, showing an inverse
relationship to that in astrocytes. These findings suggest
possible induction of GFAP or a related protein in
hippocampus neurons depending on the severity of brain
swelling following head injury.
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