Publication: Immunomodulatory functions of mesenchymal stem cells and possible mechanisms
Authors
Wang, Qing ; Ding, Gang ; Xu, Xin
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-750
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info:eu-repo/semantics/article
Description
Abstract
In addition to their well-studied self-renewal
capabilities and multipotent differentiation properties,
mesenchymal stem cells (MSCs) have been reported to
possess profound immunomodulatory functions both in
vitro and in vivo. More and more studies have shown
that MSCs are capable of interacting closely with almost
all subsets of immune cells, such as T cells, B cells,
dendritic cells, natural killer cells, macrophages, and
neutrophils etc. The immunomodulatory property of
MSCs may shed light on the treatment of a variety of
autoimmune and inflammation-related diseases. In this
article, we will review the studies on the immunomodulatory and anti-inflammatory functions of MSCs
and the mechanisms responsible for the interaction
between immune cells and MSCs, which could improve
the development of promising approaches for cellmediated immune therapies.
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Citation
Histology and Histopathology, Vol.31, nº9, (2016)
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