Publication: Electron microscopy and immunostaining of the normal breast and its benign lesions. A search for neuroendocrine cells.
Authors
Nesland, Jahn M. ; Sigurd, Lunde ; Holm, Ruth ; Johannessen, Jan Vicents
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Specimens from 7 patients with normal breast
tissue 26 patients with benign breast lesions (6
fibroadenomas, and 4 intraductal papillomas, 2 mammae
lactantes, 10 cases of cystic disease and 4 fibrotic lesions)
were studied by immunocytochemistry and electron
microscopy. Excretory epithelial cells in 2 of the 4
papillomas were immunostained for NSE. Myoepithelial
cells were frequently stained as well. All the breast
specimens were nonreactive to the antichromogranin
antibody we used.
The 2 NSE positive intraductal papillomas were tested
for presence of hormone immunoreactivity, but no
positively stained cells were observed.
No cells with neuroendocrine features were observed
by electron microscopy.
The present study did not reveal neuroendocrine cells
in the normal breast specimens and undisputed proof of
neuroendocrine differentiation in benign breast lesions was
not established. We conclude that if neuroendocrine cells
are present in the normal breast, they are very rare, and
probably not the cellular origin of all breast carcinomas
with neuroendocrine features.
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