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Staining of MUC1 in ovarian cancer tissues with PankoMab-GEX™ detecting the tumour-associated epitope, TA-MUC1, as compared to antibodies HMFG-1 and 115D8

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dc.contributor.authorDian, Darius
dc.contributor.authorLenhard, Miriam
dc.contributor.authorMayr, Doris
dc.contributor.authorHeublein, Sabine
dc.contributor.authorKarsten, Uwe
dc.contributor.authorGoletz, Steffen
dc.contributor.authorKuhn, Christina
dc.contributor.authorWiest, Irmi
dc.contributor.authorFriese, Klaus
dc.contributor.authorWeissenbacher, Tobias
dc.contributor.authorJeschke, Udo
dc.date.accessioned2018-02-19T10:35:37Z
dc.date.available2018-02-19T10:35:37Z
dc.date.issued2013
dc.description.abstracty. PankoMab-GEX™ is a novel humanized and glycooptimized antibody, which recognizes a novel specific tumour epitope of MUC1 (TA-MUC1). The aim of this study was to evaluate PankoMab-GEX™ binding to a variety of ovarian cancer specimens (n=156) and to normal ovarian tissue. In addition, PankoMab-GEX™ staining was compared to that of the well-known antiMUC1 antibodies HMFG-1 and 115D8. PankoMabGEX™ showed positive reactivity in serous (100% of cases, mean IRS 8.23), endometrioid (95% of cases, mean IRS 6.40), mucinous (58% of cases, mean IRS 4.17), and clear cell (92% of cases, mean IRS 7.58) carcinomas. In contrast to HMFG-1, healthy ovarian tissue was not recognized by PankoMab-GEX™. Staining with antibody 115D8 was increased with staging. Cytoplasmic PankoMab-GEX™ staining increased with tumour grade, but no correlation was found with staging. Univariate Kaplan-Meier analysis revealed a tendency of reduced survival of patients with high expression of TA-MUC1. The findings are encouraging with respect to a potential use of PankoMab-GEX™ as a new therapeutic antibody for the treatment of ovarian cancer patients.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.eisbnHistology and Histopathology, vol.28, nº 2, (2013)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/56226
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOvarian canceres
dc.subjectMUC1es
dc.subjectPankoMab-GEX™ immunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleStaining of MUC1 in ovarian cancer tissues with PankoMab-GEX™ detecting the tumour-associated epitope, TA-MUC1, as compared to antibodies HMFG-1 and 115D8es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 2 (2013)