Publication: Degenerative changes of the interface membrane as a possible reason for prosthesis loosening
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Date
2008
Authors
Krohmer, Gerhard ; Koleganova, Nadezda ; Hadjicostas, Panayiotis T. ; Fink, Bernd ; Berger, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: The aim of the present study was
to perform a comparative evaluation of septic and
aseptic interface membranes, assessing histological
features, inflammatory infiltrate, and expression of
inflammatory cytokines. Methods: Septic and aseptic
interface membranes from 102 patients were examined
by histology, histochemistry, and immunohistochemistry
(tissue arrays). The cell subpopulations were
characterized by quantification of CD3, CD4, CD8,
CD20, and CD163 positive cells. Additionally, a
semiquantitative evaluation of inflammatory cytokines
(TNFa, TGF-ß1, IL-1, IL-6, CRP, MMP-1, MMP-6) was
performed to complete the analysis of inflammatory
infiltrates. Results: The histological analysis revealed
three different types of aseptic interface membranes:
wear particle, degenerative, and mixed type. The
expression of inflammatory molecules did not differ
between septic and wear particle interface membranes.
Significantly lower expression of cytokines, MMPs and
CRP was observed, however, in degenerative interface
membranes compared to other types. No expression of
TNFa was observed in the degenerative interface
membranes. Over 88% of patients with degenerative
interface membranes had had a clinical record of
osteoarthritis. Conclusion: Aseptic interface membranes
were represented by wear particle, degenerative and
mixed type. The expression of inflammatory factors in
wear particle type is similar to this in septic membranes
and can contribute to the bone destruction and prosthesis
loosening. These factors seem not to play a major role in
the degenerative membranes.
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