Publication: Morphological changes of autoclaved
autogenic bone implantation and autoclaved
autogenic bone supplernented with allogenic
demineralized bone matrix in rat parietal bone
Authors
Young, T.Q. ; Matsuda, Mikio ; Takekawa, M. ; Ohtsubo, S. ; Tsuyama, K. ; Kita, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The healing process of resected, autoclaved
(121 7,20 minutes) and re-implanted bone in the rat
parietal bone was compared with that of autoclaved bone
that was supplemented with allogenic bone matrix
(AAA-bone), using a scanning electron microscope and
a light microscope.
In the implant without AAA-bone, bone union and
replacement of the autoclaved bone was seen at 2 weeks
after implantation. There was no evidence of any
inflammatory reaction around the autoclaved bone. The
implant was gradually replaced by the new bone. In the
implant with AAA-bone, the new bone formation around
the implanted bone was more abundant than that of the
implant without AAA-bone. An inflammatory reaction
was also observed after 1 week. The replacement of the
implant with AAA-bone was inferior to the nonsupplemented
group. The reason for the poor
replacement was the disturbance of the blood supply in
the implant by abundant new bone formation.
In these results, the autoclaved bone re-implantation
was an excellent bone substitute with osteoconductive
ability and biocompatibility. The implantation with
AAA-bone was good for the new bone formation, but
the position and the technique of supplement with AAAbone
have to be more deeply investigated.
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