Publication: The CCL27-CCR10 axis contributes to promoting proliferation, migration, and invasion of lung squamous cell carcinoma
Authors
Li, Baijun ; Wei, Caizhou ; Zhong, Yonglong ; Huang, Jianwei ; Li, Rizhu
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-525
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info:eu-repo/semantics/article
Description
Abstract
Lung cancer is characterized by its high
mortality and morbidity. A deep understanding of the
molecular mechanisms of lung cancer tumorigenesis
helps to develop novel lung cancer diagnostic and
therapeutic strategies. However, the picture of the
associated molecular landscape is not yet complete. As
understood, chemokine-receptor interactions contribute
much to lung cancer tumorigenesis, in which CCR10
also plays an important role. This study aimed to expand
the knowledge of CCR10 in lung squamous cell
carcinoma (LUSC) in the manner of molecular
mechanism and biological functions. Using GEPIA
database, the survival analysis between LUSC patients
with high and low CCR10 expressions was performed,
showing that CCR10 could be regarded as a risk factor
for LUSC patients. Subsequently, CCR10 protein and
mRNA expressions in LUSC were examined by qRTPCR and western blot respectively. The results indicated
that CCR10 was highly expressed in LUSC cells. The
results of CCK-8, colony formation, and Transwell
assays presented that CCL27, the ligand of CCR10,
promoted proliferative, migratory, and invasive abilities
of LUSC cells by activating CCR10. Also, the
PI3K/AKT signaling pathway was verified as the
involved pathway by western blot. Overall, it could be
concluded that the CCL27-CCR10 regulatory axis can
activate the PI3K/AKT pathway fostering the malignant
features of LUSC cells.
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Citation
Histology and Histopathology Vol. 38, nĀŗ3 (2023)
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Este Ćtem estĆ” sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/