Publication: CD10 is frequently expressed in classical seminomas
Authors
Del Sordo, Rachele ; Ascani, Stefano ; Bellezza, Guido ; Ferri, Ivana ; Sbaraglia, Marta ; Sidoni, Angelo
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. CD10 is a cell surface metalloproteinase
widely expressed in various normal tissue and in
epithelial, stromal or both components of various
malignancies. The aim of our study was to investigate,
for the first time, the expression of CD10 in a series of
135 cases of testicular germ cell tumours in order to
asses its possible diagnostic and biologic significance.
The expression of CD10 was studied, using
immunohistochemistry, in 96 pure forms and 39 mixed
forms of germinal cell tumours of the testis.
Immunostaining for CD10 was positive in 68/74
(92%) seminomas and 16/24 (67%) seminomatous
component of mixed germ cell tumours. The intratubular
germ cell neoplasia of the unclassified type always
expressed CD10. Anaplastic seminomas, embryonal
carcinomas, teratoma and spermatocytic seminomas
were negative for CD10.
Our findings indicate that only seminomas and
intratubular germ cell neoplasia, the precursors of germ
cell tumours, express CD10, but when they differentiate
along embryonal, somatic, trophoblastic, yolk sac lines
they lose CD10 expression.
CD10 could be considered a useful marker to
differentiate seminoma from other forms of testicular
germ cell tumours and for a better estimation of the
seminomatous component in mixed germ cell tumours.
Citation
Histology and Histopathology, vol. 29, nº 1, (2014)
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