Publication: Review of mucinous tubular and
spindle-cell carcinoma of the kidney with
a focus on clinical and pathobiological aspects
Authors
Kuroda, Naoto ; Toi, M. ; Hiroi, Makoto ; Shuin, T. ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Recently, the characterization of mucinous
tubular and spindle-cell carcinoma (MTSCC) has been
established. MTSCC predominantly occurs in females.
This tumor is histologically characterized by
eosinophilic cytoplasm, elongated and anastomosing
tubules, myxomatous stroma and low-grade nuclear
cytology. Proliferation of spindle cells or foci of clear
cells are also observed. Histochemically, the
myxomatous stroma exhibits a positive reaction for
alcian blue and colloidal iron stainings. Ultrastructurally,
short microvilli are focally observed and junctional
complexes are present. Recently, multiple losses of
chromosomes 1, 4, 6, 8, 9, 13, 14, 15 and 22 in MTSCC
have been elucidated by using comparative genomic
hybridization. The prognosis of MTSCC is generally
favorable, but some cases may show local recurrence or
metastasis. Some cases with MTSCC seem to show
overlapping histology with low-grade collecting-duct
carcinoma. Therefore, further investigation will be
needed to elucidate pathobiological characteristics of
MTSCC.
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