Publication: Pancreatic islet (of Langerhans) revisited
Authors
Mandarim de Lacerda, Carlos A.
item.page.secondaryauthor
item.page.director
Publisher
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-18-118
item.page.type
info:eu-repo/semantics/article
Description
Abstract
One hundred and fifty years ago, Paul
Langerhans described what would come to be known as
pancreatic ‘islet of Langerhans’. Since then, we have
accumulated knowledge about the pancreatic islet, the
cells that exist there and the hormones secreted by these
cells. The increasing prevalence of obesity, diabetes and
Alzheimer’s disease in the population (three conditions
that are linked to pancreatic islet function), the islet has
been playing a significant role in endocrinological and
metabolic studies searching how we can protect the
pancreatic islet and its cell content, or how we can
regenerate it. This review will be interested in the most
recent and relevant aspects of knowledge regarding the
pancreatic islet, always mentioning the evolution of
knowledge and future perspectives for the treatment of
diabetes and Alzheimer’s disease. The most recent
research with microRNAs and islet culture and
pseudoislet culture (organoids) allows predicting
advances in knowledge with new drugs to act on the
islet/cells (such as the hormone glucagon-like peptide
(GLP) -1) as well as induction of other islet cells like
alpha-cells and delta-cells to transform into beta-cells.
publication.page.subject
Citation
Histology and Histopathology, Vol.34, nº9, (2019)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/