Publication: MIR376 family and cancer
Authors
Tekirdag, Kumsal Ayse ; Akkoc, Yunus ; Kosar, Ali ; Gozuacik, Devrim
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-752
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info:eu-repo/semantics/article
Description
Abstract
MicroRNAs (miRNAs) are endogenous noncoding small RNAs that negatively regulate gene
expression at the post-transcriptional level. They have
been implicated in several fundamental biological
processes including development, differentiation,
apoptosis and stem cell maintenance. There is increasing
evidence that microRNAs also play roles in cellular
transformation and carcinogenesis by acting either as
tumor suppressors or oncogenes. Recent studies
introduced MIR376 as an important microRNA family
for cancer formation and progression. The MIR376
family is located on human chromosome 14 and it has
several members containing identical or similar seed
sequences. Biological roles of family members were
studied in different cancer settings, including gliomas,
leukemia, breast and ovarian cancers. Furthermore, two
MIR376 family members, namely MIR376A and
MIR376B were implicated in the regulation of
macroautophagy (autophagy herein). Since autophagy
dysregulation underlies various diseases including
cancer, it is essential to understand the role of the
MIR376 family in this context. In this article, we
summarize the miRNA-cancer connection, and review
accumulating data about the involvement of the MIR376
family in cancer biology.
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Citation
Histology and Histopathology, Vol.31, nº8, (2016)
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