Publication: Prognostic significance of nuclear and cytoplasmic expression of metallothioneins as related to proliferative activity in squamous cell carcinomas of oral cavity
Loading...
Date
2008
Authors
Szelachowska, Jolanta ; Dziegiel, Piotr ; Jelen-Krzeszewska, Joanna ; Jelen, Michal ; Tarkowski, Radoslaw ; Wlodarska, Iwona ; Spytkowska, Barbara ; Gisterek, Iwona ; Matkowski, Rafal ; Kornafel, Jan
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Metallothioneins (MT) are low molecular
weight proteins with high metal and cystein contents.
This study was designed to test the hypothesis that
cytoplasmic and nuclear MT expression are of
prognostic importance in patients with squamous cell
carcinomas of the oral cavity, treated by surgery with
subsequent radiotherapy. The second aim of the study
was to test the potential correlation between the nuclear
and cytoplasmic MT expressions as compared to
expression of proliferation markers and other
clinicopathological variables. Material and Methods:
The studies were performed on tumor samples from 50
patients with diagnosis of squamous cell carcinoma of
the oral cavity floor or of oral part of the tongue. All the
patients were subjected to radical surgery, accompanied
by removal of lymph nodes and post-operative
radiotherapy. Results: No significant correlation could
be detected between percentage and intensity of MT
expression on one hand and proportions of cells with
Mcm-2 (minichromosome maintenance protein 2), Ki-67
expressions, nor the grade of malignancy (G) on the
other. A significantly shorter survival was detected among patients with tumors of MT expression rated 9 or
12 according to the Remmele scale and among patients
with a high percentage (> 50%) of nuclear MT staining.
In mulivariate analyses, only OTT (Overall Treatment
Time), lymph node involvement and high expression of
Mcm-2 were found to be independent risk factors for
decreased patient’s survival. Conclusion: This is relevant
evidence that MT overexpression could be related to
worse prognosis in patients with oral cancer. We have
found no relationship between MT expression and
proliferative activity.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.