Publication: The suppressive effects of miR-1180-5p on the proliferation and tumorigenicity of bladder cancer cells
Authors
Ge, Qiangqiang ; Wang, Chenghe ; Chen, Zhong ; Li, Fan ; Hu, Jia ; Ye, Zhangqun
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-772
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info:eu-repo/semantics/article
Description
Abstract
In our previous research, we have reported
that a candidate microRNA (miR-1180-5p) has the
capacity to induce overexpression of tumor suppressor
gene p21 and inhibit the growth of human bladder
cancer (BCa) cell lines in vitro. However, the exact
mechanism as to how miR-1180-5p suppresses BCa cell
proliferation remains unknown, and the inhibitory effect
of miR-1180-5p in vivo also need to be investigated. In
the present study, we found that the expression level of
miR-1180-5p was lower in BCa cells than in normal
human urothelial cells. Furthermore, we found that
overexpression of p21, activated by miR-1180-5p,
interfered with cell cycle progress by inhibiting the cell
cycle related proteins (CDK4, CDK6, Cyclin D1 and
Cyclin A2), and thereby suppressed BCa cell
proliferation. In addition, miR-1180-5p also suppressed
the tumor growth in vivo significantly. Taken together,
our study provides evidence that up-regulation of p21 is
mainly responsible for the suppressive effect of miR1180-5p on BCa cells and miR-1180-5p can significantly
inhibit tumorigenicity in vivo.
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Citation
Histology and Histopathology, Vol.32, nº1, (2017)
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