Publication: Spatial expression of the
Kallikrein-Kinin system during nephrogenesis
Authors
El-Dahr, S.S.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
During nephrogenesis, new nephrons are
induced in the periphery of the kidney, while maturing
nephrons occupy a deeper position in the renal cortex.
This centrifugal pattern of maturation is characterized by
nephron patterning, establishment of proximal-distal
segment identity, tubular and glomerular growth and
differentiation, and acquisition of specialized functions.
All of these processes are coordinated in time and space
with renal vasculogenesis, glomerulogenesis and
regional hemodynamic changes. The end-result ensures
that tubular structure and function are tightly
coordinated with glomerular filtration during normal
kidney development. To achieve this delicate task of
glomerulotubular balance, the developing kidney
produces growth factors and vasoactive hormones that
act in a paracrine manner to regulate nephrovascular
growth, differentiation and physiological functions. One
such paracrine system is the kallikrein-kinin system
(KKS), which generates bradykinin (BK) from the
cleavage of kininogen by kallikrein.BK activates a Gprotein
coupled receptor, B2R, to regulate renal blood
flow and salt and water excretion. The developing
kidney expresses an endogenous KKS. Expression of the
KKS components and B2R is intimately coordinated
with the terminal differentiation of the distal nephron.
Kallikrein marks the onset of connecting tubule
development, whereas kininogen and B2R map to the
developing ureteric bud branches and maturing
collecting ducts.Gene targeting studies indicate that the
fetal KKS plays an important role in the maintenance of
terminal epithelial cell differentiation.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.