Publication: Effects of light deprivation on prolactin cells in golden hamsters: an immunoelectron microscopic study
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Date
1992
Authors
Seu-Mei Wang ; Jiahn-Chun Wu ; Chia-Man Lue ; An-I Tsai ; Wen-Ping Chen ; Huai-San Lin
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the golden hamster light deprivation has
been shown to induce gonadal regression and
reduction of pituitary and plasma levels of prolactin
(PRL). In the present study we examined changes in
morphology and population ratios of three types of
PRL cells 8 weeks after light deprivation, by means of
blinding or exposure of hamsters to continuous
darkness. In the pituitary of intact hamsters of either
sex, which were entrained to a 14-h light: 10-h dark
cycle, Type C cells with large secrtetory granules were
the most numerous and Type A with smalier granules
the least. After light deprivation the pituitary was
found to contain remarkably atrophic PRL cells and
showed a profound change in population ratio of PRL
cell types, Le., Type A cells prevailed over the other
two types. Pituitary glands from light-deprived and
concurrently pinealectomized hamsters exhibited
structures and a population ratio of three types of PRL
cells similar to those from intact animals. It is
suggested that small-granule-containing PRL cells
represent an inactive stage of PRL cells, whereas
medium- and large-granule-containing cells are
functionally active cells. The atrophy of PRL cells can
account for the decreased pituitary leve1 of PRL in
light-deprived hamsters reported previously.
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