Publication: Histological evaluation of scar tissue inflammatory
response: the role of hGH in diabetic rats
Authors
García-Esteo, F. ; Pascual, G. ; García-Honduvilla, N. ; Gallardo, A. ; San-Román, J. ; Bellón, J.M. ; Buján, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This paper describes a polymer site-specific
delivery system containing human growth hormone in an
in vivo model of scarring in the diabetic state.
Copolymer discs with the hormone were introduced
into incisions made in rats previously injected with
streptozotocin in order to induce diabetes. Tissue
specimens for evaluation were obtained at 3, 7 or 10
days after the procedure. Study groups were healthy rats
and diabetic rats untreated or treated with/without the
hormone. Histological sections were prepared for light
microscopy examination of wound zones.
Three and 7 days after surgery, polymer remains
could be observed in the subcutaneous tissue. These
remnants induced a moderate foreign body reaction. The
number of macrophages detected was directly related to
neovessel formation and metalloelastase expression. The
CD4+/CD8+ ratio was low during the initial follow up
stages (3 and 7 days) in untreated diabetic rats, yet an
increased ratio corresponding to areas around the
polymer remains was noted in the animals treated with
copolymer loaded with the growth hormone.
Copolymer is biodegradable in vivo and may be used
as a vehicle for the slow release of active substances.
The presence of the hormone at the site of skin injury
induces cell proliferation and enhances the repair
process.
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