Publication: Expression of Reg IV and Hath1 in neuroendocrine neoplasms
Authors
Heiskala, Kukka ; Arola, Johanna ; Heiskala, Marja ; Andersson, Leif C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Reg IV (RELP), a Regenerating protein
family member, is constitutively expressed in
neuroendocrine cells of the intestinal mucosa. The helixloop-helix
transcription factor Hath1 is the human
homologue of murine Math1, which regulates the
embryonic differentiation of neural and intestinal
secretory lineage cells. Hath1 is constitutively expressed
in a subset of mature secretory gastrointestinal cells. We
investigated by immunohistochemistry the expression of
Reg IV and Hath1 in 63 neuroendocrine tumors.
Intestinal neuroendocrine neoplasms showed coexpression
of Reg IV and Hath1, as did parathyroidal
and Merkel cell tumors. Lung small-cell carcinoma and
gastric mucocellular carcinoma expressed only Reg IV.
Pancreatic islet-derived tumors, pheochromocytomas,
and paragangliomas expressed only Hath1. Lymph node
and liver metastases retained the tissue-specific
expression patterns. These distinct expression profiles
may be useful for differential diagnostics of metastatic
lesions of neuroendocrine tumors. The dissimilar
expression patterns suggest that the proteins belong to
different signaling pathways and are activated at
different stages of neuroendocrine differentiation. Local
Reg IV expression may be influenced by the growth
factors bFGF and HGF and/or their receptors CD138 and
c-met, which were found to co-localize with Reg IV in
intestinal neuroendocrine tumors.
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