Publication: HLA molecule expression in cutaneous squamous cell carcinomas: an immunopathological study and clinical-immunohistopathological correlations
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Date
1993
Authors
García-Plata, D. ; Mozos, E. ; Carrasco, L. ; Solana, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A correlation between the lack of MHC class
1 gene expression on murine tumor cells and their ability
to grow and metastasize has recently been established.
This paper studies HLA-ABC and HLA-DR antigen
expression in tumor cells and mononuclear infiltrate of
26 cutaneous squamous cell carcinomas (SCC).
Our results showed a heterogeneous expression of
HLA class 1 molecules in these tumors. No significant
correlation between the degree of HLA class 1 molecule
expression and anatomical-clinical parameters was
found. Class 11 antigen expression was correlated to the
histopathological type and to the degree of cell
differentiation. Most mononuclear cells infiltrating the
tumor were T-lymphocytes. No correlation with
anatomical-clinical parameters was found.
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