Publication: The clinicopathological and prognostic characteristics of mucinous micropapillary carcinoma of the breast
Authors
Sun, Yangyang ; Gu, Wenxian ; Wang, Gengfang ; Zhou, Xiaoli
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-436
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info:eu-repo/semantics/article
Description
Abstract
Background. Mucinous micropapillary
carcinoma (MMPC) is a unique subtype of breast cancer,
and there is as yet no detailed report on the clinical
characteristics of MMPC.
Methods. MMPC, pure mucinous breast carcinoma
(PMBC), and invasive micropapillary carcinoma (IMPC)
samples were enrolled simultaneously, and
immunohistochemistry analysis was performed to
explore the clinicopathological attributes of MMPC.
Moreover, survival analyses of MMPC were performed
among the MMPC, PMBC, and IMPC groups and within
the MMPC group.
Results. The results showed that MMPC
demonstrated distinct pathological features and that
vascular invasion and lymph node metastasis were two
significant clinical attributes of MMPC. MMPC leads to
a shorter survival time than PMBC but an increased
survival time compared to IMPC, while the tumor-nodemetastasis stage and lymph node metastasis were
identified as two independent prognostic elements for
disease-free survival in discerning the MMPC prognosis.
Conclusions. The gathered data implied that further
understanding and classification of MMPC may provide
better individualized therapeutic strategies for MMPC
treatment
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Citation
Histology and Histopathology Vol. 37, nº7 (2022)
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