Publication: Repair in avascular tissues, fibrosis in the transparent structures of the eye and thrombospondin 1
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Date
1999
Authors
Hiscott, P. ; Armstrong, D. ; Batterbury, M. ; Kaye, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Wound repair is a process which is normally
dependent on the vasculature of the damaged tissue.
However, the transparent structures of the eye (e.g.
central cornea, lens, vitreous) are avascular and yet are
still subject to repair and fibrosis. Moreover, the
resulting ophthalmic scars often remain avascular. Since
this type of ocular scarring may result in blindness, it is
the subject of intense research. An aspect of avascular
ophthalmic fibrosis which has attracted attention is the
question concerning early wound healing components
that are usually derived from blood constituents. One
such molecule is the glycoprotein thrombospondin 1.
Thrombospondin 1 is thought to be a key regulator of
cell behaviour in early wound repair and appears to be
derived totally from platelet cc-granules during repair of
incisional skin wounds. It has been shown that the ocular
cells involved in avascular repair processes, and which
are thus responsible for healing in the absence of
platelet-derived thrombospondin 1, are capable of
synthesizing the protein themselves. It is suggested that
cells involved in ophthalmic repair processes produce
thrombospondin 1 in the absence of the platelet-derived
molecule. Local synthesis of thrombospondin 1 may
represent a therapeutic target in the management of
ophthalmic fibrosis.
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