Publication: Physical forces and non linear dynamics mould fractal cell shape. Quantitative morphological parameters and cell phenotype
Authors
Bizzarri, M. ; Pasqualato, A. ; Cucina, A. ; Pasta, V.
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell shape is mainly determined by
biophysical constraints, interacting according to nonlinear
dynamics upon the basic units provided by the
genome. In turn, the specific configuration a cell
acquires plays a fundamental, permissive role in
modulating gene expression and many other complex
biological functions. Cell shape is tightly connected to
cell activity and can be considered the most critical
determinant of cell function. As a consequence,
measurable parameters describing shape could be
considered as ‘omics’ descriptors of the specific level of
observation represented by the cell-stroma system. Such
an approach promises to formalize some of the
underlying basic mechanisms and, ultimately, provide a
holistic understanding of the biological processes.
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