Publication: Integrins in ageing cartilage tissue in vitro
Authors
Shakibaei, M. ; Abou-Fiebye, H. ; Merker, H. J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Matrix-cell interactions are of great
irnportance for numerous cell functions whereby
integrins play an essential role as transmicters of extracellular
signals. In cultures of ageing cartilage tissue
(organoid or high density cultures) cartilage cells occur
on the surface of which thick fibrils of collagen type 1
are deposited. Since integrins, in their role as receptors,
cause an interaction between matrix components and cell
membrane, we tried to demonstrate immunomorphologically
(light and electron microscopically) the
corresponding integrin receptors for collagen type 1
(B, al and B1%) on the surface of these ageing cartilage
cells. Cultures of normal, i.e. young cartilage tissue
exhibit only Ola3- and Bla5~receptorsl;a belling against
the integrins Blal and Bla2 1s not possible in this case.
Our results show that after the occurrence of thick fibrils
cartilage cells express new receptors (Blal and fila2)o n
the cell membrane. Thus, in ageing or dedifferentiating
cartilage tissue it is not only the synthesis programme of
matrix components (e.g. instead of collagen type 11 >>
collagen type 1) which changes but also the integrins
(instead of a3/B1, a51Bl >> allB1, a2/B1) so that new
collagen types can be bound. These findings may also
serve for a better understanding and interpretation of
cartilage changes in vivo during ageing and under
pathological conditions.
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