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Primary tumor vascularity in esophagus cancer. CD34 and HIF1-α expression correlate with tumor progression

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dc.contributor.authorGoscinski, Mariusz Adam
dc.contributor.authorNesland, Jahn M.
dc.contributor.authorGiercksky, Karl- Erik
dc.contributor.authorDhaka, Hari Prasad
dc.date.accessioned2018-09-10T17:45:25Z
dc.date.available2018-09-10T17:45:25Z
dc.date.issued2013
dc.description.abstractObjective: Hypoxia inducible factor α (HIF1-α) is a key protein regulating the response of a variety of genes and pathways, including angiogenesis, to hypoxic stimuli. High vascularity in various carcinomas correlates with invasion and metastasis. Assessment of primary tumor vascularity and HIF1-α expression in esophageal carcinomas was an objective of this study. Methods: The vascularity in esophageal carcinomas (n=52) was quantified by Chalkley method on CD34 immunostained sections. HIF1-α expression was examined by immunohistochemistry. The relationships between CD34 Chalkley count, HIF1-α and various clinico-pathological characteristics with clinical outcome were evaluated. Results: High HIF1-α expression in squamous cell carcinoma (SCC) was significantly associated with the T3-4 group (p=0.02). A higher percentage of SCC with high HIF1-α expression compared to its expression in adenocarcinoma (AC) (p=0.005) was observed. In the SCC group, high CD34 Chalkley count and high HIF1-α expression implied a significantly reduced survival (p=0.003 and p=0.001). No such significant association was found in the AC group. Conclusions: HIF1-α expression is different in two separate tumor microenvironments: SCCs and ACs of the esophagus. This suggests that different mechanisms may be involved in HIF1-α expression- and activity between the two histological types of esophageal carcinoma.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.eisbnHistology and Histopathology, vol. 28, nº 10 (2013)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/60980
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEsophageal canceres
dc.subjectPrimary tumor vascularityes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titlePrimary tumor vascularity in esophagus cancer. CD34 and HIF1-α expression correlate with tumor progressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº10 (2013)