Publication: The metastasis-associated gene MTA3 is downregulated in advanced endometrioid adenocarcinomas
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Date
2010
Authors
Brüning, Ansgar ; Jückstock, Julia ; Blankenstein, Thomas ; Makovitzky, Josef ; Kunze, Sussane ; Mylonas, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The metastasis-associated gene MTA3 has an
important function in invasion and metastasis of human
cancer cells. Therefore, the aim of this study was to
investigate the expression of this protein in endometrial
adenocarcinomas and to analyse potential correlations
between this nuclear transcription factor and estrogen
receptors in endometrial adenocarcinomas. Additionally,
we evaluated whether MTA3 might be a prognostic
parameter in endometrioid adenocarcinomas.
Endometrioid adenocarcinomas were obtained from 200
patients and immunohistochemically analysed for MTA3
and estrogen receptor alpha and beta (ER-alpha and ERbeta)
expression. Overall, endometrioid adenocarcinomas
of histological differentiation grade 3
demonstrated a significantly lower expression of MTA3
compared to carcinomas of histological grade 1 and 2
(p<0.05). MTA3 expression is reduced in endometrioid
adenocarcinomas of poor differentiation, though without
any correlation to ER-alpha and ER-beta expression.
Furthermore, the expression of MTA3 did not affect
progression-free, cause-specific and overall survival.
Overall, MTA3 did not constitute an independent
prognostic factor in this study, suggesting that MTA3 is
not a useful marker to assess and identify high-risk
patients with endometrial adenocarcinomas. Still, the
downregulation of MTA3 predispose this cell type to be
of high metastatic potential after malignant
transformation, playing an essential, but as yet unknown
role in human endometrial carcinogenesis.
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