Publication: FAM107A inhibits invasion and migration of colorectal cancer by affecting EMT via the AKT pathway
Authors
Zhenyu Dai ; Wenhui Li ; Jun Zhu ; Chunlong Li ; Rui Huang ; Haoguang Wan ; Yue Liu ; Lizhou Chen
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-25-024
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info:eu-repo/semantics/article
Description
Abstract
Metastasis of colorectal cancer (CRC) is the
main cause of CRC-related mortality. FAM107A is
widely expressed in various normal tissues. However,
few studies have revealed the biological function of
FAM107A in epithelial-mesenchymal transition (EMT)
in human cancer cells, and the related molecular
mechanisms and signaling cascades are completely
unknown. Here, we found that FAM107A was
abnormally expressed in human CRC tissues and cell
lines. Further research has shown that overexpression of
FAM107A through transfection weakened the expression
level of EMT-related markers. In addition, our research
results indicated that upregulation of FAM107A
inhibited the AKT signaling cascade in human CRC
cells, while AKT activators restored activation of p50,
indicating that FAM107A may regulate EMT through
AKT activation of p50. Our results suggest that
FAM107A could be a potential target for the treatment of
CRC.
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Citation
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