Publication: The response of subpleural pulmonary capillary
endothelium to hydrothorax in rats
Authors
Shumko, John Z. ; DeFouw, David .
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The principal focus of this study was to
evaluate the hypothesis that increased interstitial fluid
pressures served to stimulate de novo vesicle formation in
pulmonary capillary endothelium. Direct measurements of
interstitial fluid pressures within the alveolar septa pose
great technical difficulty. The pleural space and subpleural
capillaries are easily accessible, and thus, provide a more
feasible model to test this hypothesis. After hydrostatic
pressure of pleural space fluid was increased by periodic
saline infusions into the pleural cavity, vesicle numerical
densities were significantly increased in portions of the
subpleural capillary endothelium. Those segments of the
endothelium that directly apposed the interstitium of the
visceral pleura displayed de novo vesicle formation. The
endothelial segments located immediately adjacent to the
alveolar epithelium were not affected by the elevated
interstitial fluid pressures. In addition to the increased
vesiculation, those same segments of the endothelium were
characterized by increased attenuation of their cytoplasmic
compartments. These conformational changes in the
plasmalemma of portions of the subpleural capillary
endothelium provide support to the tentative hypothesis,
however, whether the increased numbers of vesicles
contribute to a potential transendothelial transport system
or expand a possible static network of membrane
invaginations remains uncertain.
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