Publication:
CXCR3 in carcinoma progression

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dc.contributor.authorMa, Bo
dc.contributor.authorKhazali, Ahmad
dc.contributor.authorWells, Alan
dc.date.accessioned2020-09-25T11:55:39Z
dc.date.available2020-09-25T11:55:39Z
dc.date.issued2015
dc.description.abstractCXCR3 is a G-protein coupled receptor which binds to ELR-negative CXC chemokines that have been found to impact immune responses, vascular develop, and wound repair. More recently, CXCR3 has been examined in the context of cancer and increased expression in many human tumors has been correlated with poor prognosis in breast, melanoma, colon and renal cancer patients. Three variants of CXCR3 are identified so far (CXCR3-A, CXCR3-B and CXCR3-alt) with the two primary ones, CXCR3-A and CXCR3-B, considered to induce opposite physiological functions. Generally, CXCR3-A, the predominant form in hematopoietic cells, appears to mediate tumor “go” signaling via promoting cell proliferation, survival, chemotaxis, invasion and metastasis; while CXCR3-B, the main form on formed elements including epithelial cells, appears to mediate tumor “stop” signaling via promoting growth suppression, apoptosis and vascular involution. Thus, aberrant expression of the isoforms CXCR3-A and CXCR3-B could affect tumor progression. In this review, we have discussed the profiles of CXCR3 variants and related signaling, as well as the role of CXCR3 variants in cancer.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, vol.30, nº7, (2015)
dc.identifier.doi10.14670/HH-11-594
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96484
dc.languageenges
dc.publisherUniversidad de Murcia. Servicio de publicacioneses
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChemokineses
dc.subjectCanceres
dc.subjectCXCR3es
dc.subjectCXCR3-Aes
dc.subjectCXCR3-Bes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCXCR3 in carcinoma progressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº7 (2015)