Publication: Expression of Foxp3 and TLR4 in human papillary thyroid carcinoma and its clinical significance
Authors
Xin, Jingwei ; Fu, Haiying ; Zhang, Jiaping ; Zou, Hongrui ; Li, Qi ; Yang, Wei ; Sun, Hui
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-524
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info:eu-repo/semantics/article
Description
Abstract
This study aimed to explore the association
of Foxp3 and TLR4 with clinical pathological
characteristics in papillary thyroid carcinoma (PTC)
patients. Methods 78 cases of PTC were used as
experimental group and 20 cases of normal thyroid
tissue were used as control group. The expression of
Foxp3 and TLR4 in thyroid tissue from the two groups
was detected by immunohistochemistry, and the
experimental group was divided into several groups on
the basis of different clinicopathological indicators. The
association between Foxp3 and TLR4 expression and
clinicopathological parameters was statistically
analyzed. Results Foxp3 and TLR4 were expressed in
higher levels in PTC than in normal thyroid tissue
(P<0.05). Foxp3 was mainly localized in the cytoplasm
and nucleus of PTC cells, while TLR4 was found in the
cytoplasm and cell membrane of cancer cells. The
expression of both proteins associated with lymph node
metastasis and TNM clinical stage (P<0.05). The
expression of Foxp3 correlated with the expression of
TLR4 in tested PTC tissues (P<0.05). In addition, the
result of confocal fluorescence microscopy showed that
Foxp3 and TLR4 co-localized in PTC cells. Conclusion
Foxp3 and TLR4 were upregulated and associated with
lymph node metastasis and advanced TNM stage in PTC
tissues. Together they may act as valuable factors for the
identification of high-risk PTC patients.
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Citation
Histology and Histopathology Vol. 38, nĀŗ3 (2023)
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Este Ćtem estĆ” sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/