Publication: Regulation of human cranial osteoblast
phenotype by FGF-2, FGFR-2 and BMP-2 signaling
Authors
Marie, P.J. ; Debiais, F. ; Haÿ, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The formation of cranial bone requires the
differentiation of osteoblasts from undifferentiated
mesenchymal cells. The balance between osteoblast
recruitment, proliferation, differentiation and apoptosis
in sutures between cranial bones is essential for calvarial
bone formation. The mechanisms that control human
osteoblasts during normal calvarial bone formation and
premature suture ossification (craniosynostosis) begin to
be understood. Our studies of the human calvaria
osteoblast phenotype and calvarial bone formation
showed that premature fusion of the sutures in nonsyndromic
and syndromic (Apert syndrome)
craniosynostoses results from precocious osteoblast
differentiation. We showed that Fibroblast Growth
Factor-2 (FGF-2), FGF receptor-2 (FGFR-2) and Bone
Morphogenetic Protein-2 (BMP-2), three essential
factors involved in skeletal development, regulate the
proliferation, differentiation and apoptosis in human
calvaria osteoblasts. Mechanisms that induce the
differentiated osteoblast phenotype have also been
identified in human calvaria osteoblasts. We
demonstrated the implication of molecules (N-cadherin,
Il-1) and signaling pathways (src, PKC) by which these
local factors modulate human calvaria osteoblast
differentiation and apoptosis. The identification of these
essential signaling molecules provides new insights into
the pathways controlling the differentiated osteoblast
phenotype, and leads to a more comprehensive view in
the mechanisms that control normal and premature
cranial ossification in humans.
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