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Immunohistochemical study of macrophage and cytokine dynamics in the gut of scrapie-infected mice

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dc.contributor.authorRomero-Trevejo, José Lorenzoes
dc.contributor.authorGómez-Villamandos, J. C.es
dc.contributor.authorPedrera, Mirian
dc.contributor.authorBlanco, Alfonso
dc.contributor.authorBautista, María José
dc.contributor.authorSánchez-Cordón, Pedro José
dc.date.accessioned2015-09-29T07:17:59Z
dc.date.available2015-09-29T07:17:59Z
dc.date.issued2010
dc.description.abstractTo study numerical changes in intestinal macrophages and variations in cytokine production by immune cells in the intestine, conventional C57BL/6J mice were orally infected with the Rocky Mountain Laboratory strain of scrapie. Animals were sacrificed at different timepoints, and samples were taken and processed by routine methods for morphological and immunohistochemical analysis. The results point to a possible role for macrophages in the uptake and transport of the infective agent to Peyer’s patches. The observed increase in macrophage numbers in subepithelial sites, taken in conjunction with a drop in tumour necrosis factor-α production at these sites, suggests a possible secretory inhibition that could be induced by the disease-associated prion protein (PrPd). On the other hand, cytokine dynamics indicated the presence of an impaired Th1-Th2 cell mediated response, which could facilitate the spread of PrPd to the central nervous system. Further research is required to confirm these hypotheses.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46328
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectScrapiees
dc.subjectCytokineses
dc.subject.other636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleImmunohistochemical study of macrophage and cytokine dynamics in the gut of scrapie-infected micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº8 (2010)