Publication: Histopathogenesis of bone- and soft-tissue tumor spectrum with USP6 gene rearrangement: multiple partners involved in the tissue repair process.
Authors
Legrand, Mélanie ; Jourdan, Marie Lise ; Pinieux, Gonzague de
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-532
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info:eu-repo/semantics/article
Description
Abstract
Primary aneurysmal bone cyst, nodular
fasciitis, myositis ossificans and related lesions as well
as fibroma of tendon sheath are benign tumors that share
common histological features and a chromosomal
rearrangement involving the ubiquitin-specific peptidase
6 (USP6) gene. The tumorigenesis of this tumor
spectrum has become complex with the identification of
an increasing number of new partners involved in USP6
rearrangements. Because traumatic involvement has long
been mentioned in the histogenesis of most lesions in the
USP6 spectrum and they morphologically resemble
granulation tissue or callus, we attempted to shed light
on the function and role USP6 partners play in tissue
remodelling and the repair process and, to a lesser
extent, bone metabolism
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Citation
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