Publication: A new morphological classification during follow-up in
patients with celiac disease. A three-dimensional
observation by scanning electron microscopy
Authors
Magliocca, F.M. ; Bonamico, M. ; Petrozza, V. ; Mariani, P. ; Correr, S. ; Familiari, G. ; Carpino, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The structure and ultrastructure of the villi of
small intestinal mucosa was examined in 237 duodenal
or jejunal biopsies taken from children with active celiac
disease and during gluten-free diet. Al1 biopsies were
processed for light and scanning electron microscopy.
Conventional histology showed four different
morphological aspects: total and subtotal villous atrophy
in patients on unrestricted diet, partial villous atrophy
and normal mucosa during gluten-free diet. Scanning
electron microscopy demonstrated that in active celiac
disease the severity of the intestinal lesions was related
to individual vulnerability to gluten. Our results showed
that during dietary treatment the process of mucosa1
healing was constant and strictly time-dependent.
Furthermore, the ultrastructural examination has been
relevant in evaluating the evolution of the villous
regeneration. In this study a classification regarding the
healing process of the small intestinal mucosa correlated
with the time of start of dietary therapy is proposed.
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