Publication: An ultrastructural examination of murine alveolar macrophages following intranasal administration of Propionibacterium acnes
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Date
1987
Authors
Hightower, James A. ; Welsh, Marcia G. ; Jackson, R.A. ; Gangemi, J. David
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Light and electron microscopic analysis of
murine lungs or isolated pulmonary cells was performed
three days after intranasal administration of the bacterial
immunostimulant, Propionibacterium acnes (P. acnes).
Our observations indicated that pulmonary alveolar and
airway macrophages (PAMs) were the only cells with
P. acnes bacilli in their cytoplasm. Bacilli were not
observed in pulmonary interstitial macrophages,
granulocytes, lymphocytes or pulmonary parenchyma1
cells such as type I and type I1 pneumocytes. Because of
the morphological heterogeneity of PAMs observed in
control and experimental animals, it was not possible
from these studies to be certain about the relative
abundance or complexity of lysosomes, endoplasmic
reticulum, Golgi and other organelles in the two groups.
However, we noted that it was not uncommon to observe
in the same PAM, profiles of P. acnes and a well
developed Golgi complex and endoplasmic reticulum.
These P. acnes - associated morphological alterations
occurred at a time when functional activities (e.g.,
phagocytosis, cytostasis) of PAMs were enhanced.
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