Publication: ATM gene expression is associated with differentiation and angiogenesis in infiltrating breast carcinomas
Loading...
Date
2006
Authors
Cuatrecasas, M. ; Santamaria, G. ; Velasco, M. ; Camacho, E. ; Hernandez, L. ; Sanchez, M. ; Orrit, C. ; Murcia, C. ; Cardesa, Antonio ; Campo, Elías ; Fernandez, P.L.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
Description
Abstract
The product of the ATM gene, mutated in the
human genetic disorder ataxia-telangiectasia (A-T) plays
a key role in the detection and repair of DNA doublestrand
breaks. A-T is defined by progressive cerebellar
ataxia, telangiectasia, sensitivity to ionising radiation
and genomic instability with cancer predisposition. On
the other hand, increased angiogenesis is essential for
tumor growth and metastasis. The aim of this study was
to investigate ATM expression in breast carcinomas and
its relationship to neoangiogenesis.
Methods and Results: Fifty-two breast tumors from
51 patients, 38 of them with concomitant in situ
component (CIS), were analyzed by immunohistochemistry
for the expression of ATM. CD34
expression was used for the morphometric evaluation of
vasculature. ATM was positive in 1 to 10% of normal
epithelial cells. ATM expression was reduced in 55.8%
of infiltrating carcinomas, non-reduced in 34.6%, and
increased in 9.6%. Expression of ATM in CIS was
similar to the infiltrating component in 71% of cases and
reduced in 23.7% of them. High-grade ductal infiltrating
carcinomas showed lower ATM expression than lowgrade
ones. Reduced ATM expression also correlated
with increased microvascular area.
Conclusions: Reduced ATM expression in breast
carcinomas correlated with tumor differentiation and
increased microvascular parameters, supporting its role
in neoangiogenesis and tumor progression in breast
carcinogenesis.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.