Publication: The dynamics of cellular injury: transformation into neuronal and vascular protection
Authors
Maiese, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Despite the immediate event, such as
cerebral trauma, cardiac arrest, or stroke that may result
in neuronal or vascular injury, specific cellular signal
transduction pathways in the central nervous system
ultirnately influence the extent of cellular injury. Yet, it
is a cascade of mechanisms, rather than a single cellular
pathway, which determine cellular survival during toxic
insults. Although neuronal injury associated with several
disease entities, such as Alzheimer's disease, Parkinson's
disease, and cerebrovascular disease was initially
believed to be irreversible, it has become increasingly
evident that either acute or chronic modulation of the
cellular and molecular environment within the brain can
prevent or even reverse cellular injury. In order to
develop rational, efficacious, and safe therapy against
neurodegenerative disorders, it becomes vital to
elucidate the cellular and molecular mechanisms that
control neuronai and vascular injury. These include the
pathways of free radical injury, the independent
mechanisms of programmed cell death, and the
downstream signal transduction pathways of
endonuclease activation, intracellular pH, cysteine
proteases, the cell cycle, and tyrosine phosphatase
activity. Employing the knowledge gained from
investigations into these pathways will hopefully further
efforts to successfully develop effective treatments
against central nervous system disorders.
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