Publication: Expression of NA-1 symporter NIS in endometrial mucosa of fertile, sterile and post-menopausal women
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Date
2008
Authors
Trovato, María ; Vitarelli, Enrica ; Tripepi, María ; Abate, Antonino ; Rizzo, Piero ; Benedetto, Vincenzo ; Sciacchitano, Salvatore ; Grosso, Maddalena ; Barresi, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The expression of the Na/I Symporter (NIS)
in the basolateral cell membrane of the thyroid follicular
cells is responsible for the active accumulation of iodide
within the thyroid gland and for the subsequent
biosynthesis of thyroid hormones. However, several
tissues, such as salivary glands, breast, stomach, colon,
ovary and endometrium, express NIS even if they are
unable to organify iodide.
In order to investigate a possible role of NIS in the
endometrium, we analyzed, by immunochemistry, the
expression of NIS in 44 endometrial samples of 20
patients with primary unexplained infertility, 14 fertile
women and 10 in postmenopausal.
NIS immunostaining was detected in endometrial
cells belonging to the majority of sterile, postmenopausal
and fertile women. However, the sterile and
post-menopausal patients showed a higher percentage of
NIS reactive cells compared to the fertile women
(60±21% and 57±18% vs 19±9%; p=0.0001). NIS
immunostaining was localized on the membrane and
cytoplasm of the endometrial cells. We could not find
any correlation between endometrial thickness and NIS
immunoexpression. Our results indicate that, in the
absence of histological markers, a sterile endometrium can be recognized because of the high expressions of
NIS. Moreover, NIS expressions, elevated in both sterile
and menopause women, is not related to the estrogen
levels, but it could be modulated by factors common to
the two conditions. In conclusion, we speculate that NIS
may play a role in the development of female sterility.
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