Publication: Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors
Loading...
Date
2007
Authors
Takenaka, Y. ; Tsukamoto, T. ; Mizoshita, T. ; Ogasawara, N. ; Hirano, N. ; Otsuka, T. ; Ban, H. ; Nakamura, T. ; Yamamura, Y. ; Kaminishi, M. ; Tatematsu, M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
We have previously suggested that an origin
of a stomach cancer is from a progenitor cell
specializing toward exocrine cell (Exo-cell) lineages. To
clarify whether our hypothesis is correct or not, we
analyzed the expression of Exo-cell and endocrine cell
(End-cell) markers in a series of lesions for comparison.
We evaluated chromogranin A (CgA) expression in 37
early and 73 advanced stomach cancers, in 30 stomach
adenomas, in 8 carcinoid tumors, and in 4 endocrine cell
carcinomas (ECCs) with assessment of gastric and/or
intestinal (G/I) phenotypes in both Exo-cell and End-cell
by immunohistochemistry. CgA expression was
observed in 10.8% of the early and 16.4% of the
advanced stomach cancers, respectively. The End-cell
G/I phenotypes were in line with the Exo-cell
counterparts in the CgA-positive stomach cancerous
areas, and there was strong association between Cdx2
expression and the intestinal End-cell markers. All of the
adenoma cases had the intestinal Exo-cell phenotypic
expression, with the positive link between Exo-cell and
End-cell G/I phenotypes. All stomach carcinoids had
CgA expression but no expression of Exo-cell markers.
In conclusion, most stomach cancers might develop from
a progenitor cell specializing towards Exo-cell lineages,
but some cases possessed both Exo-cell and End-cell
markers with maturely differentiated phenotypes. In such
cases, Exo-cell and End-cell phenotypes were found to
correlate strongly, suggesting the possibility of
histogenesis from “cancer stem cells”.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.