Publication: Sclerotic fibroma-like dermatofibroma:
an uncommon distinctive variant of dermatofibroma
Authors
González-Vela, M.C. ; Val-Bernal, José Fernando ; Martino, M. ; González-López, M.A. ; García-Alberdi, E. ; Hermana, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Dermatofibroma (DF) is a common benign
cutaneous tumor with many variants based on alterations
in the morphology and composition of its diverse
elements. One very infrequent type is sclerotic fibromalike
DF (SF-DF). We report 7 new cases of SF-DF. In
addition, their main clinicopathological and
immunohistochemical features were compared with 14
unselected common DFs and with 3 sclerotic fibromas
(SFs).
Microscopically, the 7 cases of SF-DFs showed an
unencapsulated, well-circumscribed, hypocellular central
nodule with thick collagen bundles arranged in a
storiform pattern with prominent clefts. The overlying
epidermis was attenuated. The periphery of this nodule
was more cellular with histopathologic features of
common DF. The 7 SF-DFs patients were 4 women and
3 men with a mean (±SD) age of 44.8 (±15.5) years.
These 7 patients were younger than those suffering from
SFs [71.0 (±17.3) years; (p=0.04)] and older than those
presenting common DFs [30.5 (±12.3) years; (p=0.03)].
Immunohistochemically, spindle cells in all 7 SF-DFs
were negative for CD34 and CD99. On the contrary, the
3 cases of SF were positive for CD34 and CD99. All of
the common DFs were negative for CD34 and only 4
(28.6%) of them were positive for CD99. In conclusion,
SF-DF is an uncommon variant of DF with similar
clinicopathological and immunohistochemical features.
SF-DF shares certain histopathologic features with SF
but they are immunophenotypically different. Therefore,
both entities should be differentiated.
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