Publication: HuR, a key post-transcriptional regulator, and its implication in progression of breast cancer
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Date
2010
Authors
Yuan, Zhu ; Sanders, Andrew J. ; Ye, Lin ; Jiang, Wen G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
HuR, an ubiquitously expressed member of
the Hu family, selectively binds and stabilizes AREcontaining
mRNAs encoding proto-oncogenes, cell cycle
regulators, cytokines and growth factors. The
mechanism of HuR stabilization on target mRNAs is
believed to be mediated through competition with
destabilizing ARE-BPs. HuR is mainly localized within
the cell nucleus and the nucleo-cytoplasmic shuttling of
HuR is generally assumed as the initial and critical step
of its stabilizing effects. A number of signaling pathways
are believed to be involved in HuR shuttling. Due to the
pivotal role played by HuR in stabilizing the mRNA of
key factors or cytokines involved in carcinogenesis and
subsequent progression, its implication and therapeutic
potential in cancer have been investigated intensively
since its discovery in 1996. This review discusses the
role of HuR in the stabilization of key mRNAs and it’s
the nucleo-cytoplasmic shuttling. The review also covers
the current knowledge of HuR’s role in carcinogenesis,
particularly its involvement in breast cancer, and the
feasibility of using HuR as a therapeutic target for the
treatment of breast cancer.
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